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This means that a 40-cent tablet, first sold by Bayer in 1899, was just as good at helping patients as AZ’s new drug that costs around $7 (before discounts) per daily treatment. The SOCRATES … Ticagrelor was administered as a 180-mg … [SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES] (SOCRATES) The safety and scientific validity of this study is the … SOCRATES: Ticagrelor Not Superior to Aspirin for Stroke, TIA. The SOCRATES trial showed that ticagrelor monotherapy with 90 mg BID was not superior to aspirin 100 mg daily in reducing major cardiovascular events in patients presenting with low-acuity ischemic … SOCRATES was a randomised, double-blind, controlled trial of ticagrelor versus aspirin in patients aged 40 years or older with a non-cardioembolic, non-severe acute ischaemic stroke, or high-risk transient ischaemic attack from 674 hospitals in 33 countries. By contrast, a slightly higher major haemorrhagic rate was found in PRINCE than in the Asian subgroup in the SOCRATES trial (1.5% in the ticagrelor/aspirin group in PRINCE v 0.6% in the ticagrelor used as monotherapy in SOCRATES).4 This difference could be related to the combined use of two drugs in our study.

The Platelet Inhibition and Patient Outcomes (PLATO) trial randomized 18,624 patients with ACS to ticagrelor or clopidogrel, in addition to standard care. HOUSTON, TX—It might be worth testing ticagrelor versus aspirin for preventing recurrent events in patients with nonsevere acute ischemic strokes or high-risk TIAs that are related to atherosclerotic disease, a prespecified secondary analysis of the neutral SOCRATES trial suggests.

AstraZeneca today announced results of the SOCRATES trial, assessing the efficacy of Brilinta/Brilique (ticagrelor) 90mg tablets twice daily, when compared to aspirin 100mg once daily in patients with acute ischaemic stroke or transient ischaemic attack (TIA).

Background and purpose: In the SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), ticagrelor was not superior to aspirin. At 12 months, the ticagrelor group had lower rates of CV death, MI, or stroke than clopidogrel (9.8% vs. 11.7%). May 11, 2016. In this study, ticagrelor … Ticagrelor (trade name Brilinta, Brilique, and formerly Possia) is a pharmaceutical drug used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries.It acts as a platelet aggregation inhibitor by antagonising the P2Y 12 receptor.

The SOCRATES trial, which was conducted at 674 centers in 33 countries, compared ticagrelor (Brilinta; AstraZeneca) and aspirin monotherapy in 13,199 patients with nonsevere, noncardioembolic acute ischemic stroke or high-risk TIA who had not received thrombolytic therapy and could be randomized within 24 hours of symptom onset.

The ticagrelor dose in THALES is the same as that used in the target population of patients with ischemic stroke or TIA in the SOCRATES study, in which ticagrelor was well-tolerated and had a similar safety profile as aspirin with respect to major bleeding events. 4,15 In patients with acute coronary syndrome, the same ticagrelor dose was used and treatment with ticagrelor … Ticagrelor (Brilinta, AstraZeneca) isn’t better secondary prevention for stroke patients than is aspirin, according to top-line results from the SOCRATES trial. Design. Ticagrelor was not found to be superior to aspirin in patients with acute ischemic stroke or transient ischemic attack (TIA), in terms of reducing rates of stroke, myocardial infarction (MI), or death at 90 days, according to results from the SOCRATES trial. BACKGROUND AND PURPOSE: SOCRATES (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), comparing ticagrelor with aspirin in patients with acute cerebral ischemia, found a nonsignificant 11% relative risk reduction for stroke, myocardial infarction, or death (P=0.07). The SOCRATES trial showed that ticagrelor monotherapy with 90 mg BID was not superior to aspirin 100 mg daily in reducing major cardiovascular events in patients presenting with low-acuity ischemic stroke or high-risk transient ischemic attack (TIA). Sue Hughes . SOCRATES is a multicenter, randomized, double‐blind, double‐dummy, parallel‐group superiority trial. Following these results, the SOCRATES trial was designed to investigate the comparative efficacy of ticagrelor versus aspirin in reducing a composite endpoint of recurrent stroke, MI, or death at 90 days in patients presenting with acute neurologic ischemia.

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