";s:4:"text";s:2921:"Main Difference – Nucleotide vs Nucleoside. Nucleotide and nucleoside are building blocks of nucleic acids. A nucleotide consists of carbon sugar, nitrogenous base, and phosphate group as well. The nucleotides in DNA and RNA are such nucleotides. The nucleoside analogues are an important class of antiviral agents now commonly used in the therapy of human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV), cytomegalovirus (CMV) and herpes simplex virus (HSV) infection. A nitrogenous base is covalently attached to sugar which is either ribose or deoxyribose, however, there is no presence of the phosphate group here in case of a nucleoside. 2019. BiologyWise lists out all the differences between nucleosides and nucleotides. Compare clinical endpoints and other relevant measures of treatment efficacy. Nucleotides also play a central role in metabolism at a fundamental, cellular level. Nucleoside analogs are used in medicines as antiviral and anticancer agents. Facebook . Thus a nucleoside plus a phosphate group yields a nucleotide. Nucleoside A nitrogenous base is attached to a sugar and somewhere between one to three phosphate groups in case of a nucleotide. Nucleotide vs. Both cease the synthesis of the growing viral DNA strand. Web. Thus, a nucleoside triphosphate (NTP) is a nucleoside … 5th edition. 5th edition. The file may contain a single sequence or a list of sequences. A nucleoside consists of a nucleobase and a sugar (ribose or deoxyribose) whereas a nucleotide contains a nucleobase, a sugar, and one or several phosphate groups. They are often used interchangeably, however, they are quite distinct entities. Nucleoside/nucleotide analogues in the treatment of chronic hepatitis B. Fung J(1), Lai CL, Seto WK, Yuen MF. 2017.