";s:4:"text";s:4794:"Prevalence and clonality of Burkholderia cepacia complex genomovars in UK patients with cystic fibrosis referred for lung transplantation. However, the risks posed by different Burkholderia species on transplantation outcomes are poorly defined. Background In patients with cystic fibrosis, infection with Pseudomonas cepacia is associated with poor outcomes. The effect B. cepacia has on people with CF is hard to predict. Author information: (1)Toronto Lung Transplant Program, Toronto Hospital, University of Toronto, Toronto, Ontario, Canada. As a result of concern over excessive mortality after lung transplantation, many transplant … Burkholderia cepacia, a bacteria which used to be called Pseudomonas cepacia, is a rare but significant threat to people living with cystic fibrosis (CF).While the infection is most often symptom-free, it can turn serious, and even life-threatening. As a significant … It was first discovered by Walter Burkholder, a plant scientist, in 1950, who identified it on the skin of onions. Respiratory failure secondary to chronic pulmonary bacterial infection remains the primary cause of mortality and morbidity in cystic fibrosis (CF) patients [].We investigated … Burkholderia cepacia, formerly Pseudomonas cepacia, has emerged as an important pathogen in patients with cystic fibrosis undergoing lung transplantation. Eur J Cardiothorac Surg 2002; 22: 602-609. Pre-operative infection with organisms from the Burkholderia cepacia complex (BCC), particularly B cenocepacia, has been linked with a poorer prognosis after transplantation compared to patients with cystic fibrosis (CF) without this infection.Therefore, many transplant centers do not list these patients for transplantation. Statistics on survival have been published indicating that patients with CF can undergo successful transplantation with either heart-lung 2 x 2 Yacoub, MH, Banner, NR, Khaghani, A, Fitzgerald, M, Madden, B, and Tsang, V. Heart-lung transplantation for cystic fibrosis and … Cystic fibrosis bugs. Of the 25 papers found using a report search, five presented the best evidence to answer the clinical question. OBJECTIVES: To evaluate the impact of Burkholderia cepacia complex colonization in cystic fibrosis patients undergoing lung transplantation. Infection with Burkholderia species is typically considered a contraindication leading to transplantation in cystic fibrosis (CF). Some species are …
Methods: A long term retrospective study was conducted of all patients with CF undergoing lung transplants from January 1990 to October 2006 in two French centres allowing transplantation in patients colonised with BCC. METHODS: We prospectively analyzed clinical data and respiratory tract samples (sputum and bronchoalveolar lavage) collected from suppurative lung disease patients between January 2008 and November 2013.
Egan TM, Detterbeck FC, Mill MR. Long term results of lung transplantation for cystic fibrosis. Many treatment centers consider B. cepacia infection an absolute contraindication to lung transplantation. The question addressed was whether lung transplantation remained a beneficial treatment for cystic fibrosis (CF) patients infected or colonized with Burkholderia cepacia complex (BCC) prior to lung transplantation (LTx). As a result of concern over excessive mortality after lung transplantation, many transplant programs refuse to accept cystic fibrosis (CF) patients infected with Burkholderia cepacia. Survival After Lung Transplantation of Cystic Fibrosis Patients Infected with Burkholderia cepacia Complex Alexander, B. D. ; Petzold, E. W. ; Reller, L. B. ; Palmer, S. M. ; … Methods. In addition, a targeted survey of all 251 lung transplant recipients was performed. Thorax 2004; 59: 526-528. Impact of Burkholderia Infection on Lung Transplantation in Cystic Fibrosis Susan Murray1,2, Jeffery Charbeneau1, ... infection with Burkholderia species in 1,026 lung transplant candi-dates and 528 lung transplant recipients.