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Natural killer cells as a double-edged sword in cancer immunotherapy: A comprehensive review from cytokine therapy to adoptive cell immunotherapy Author links open overlay panel Yuanlin Wu a b 1 Jing Li c 1 Parham Jabbarzadeh Kaboli a b Jing Shen a b Xu Wu a b Yueshui Zhao a b Huijiao Ji a b Fukuan Du a b Yejiang Zhou d Yongzhou Wang e …

Most investigators believe that sustained proliferations of NK cells require additional signals[23, 24], such as the presence of monocytes [] or B-lymphoblastoid cells [16, 25, 26].Miller et al. Here, Sitnicka Quinn discusses the contribution of natural killer (NK) cells to the immunosurveillance of human cancer, defects in NK cell generation and cytotoxicity, and the benefits of a ‘universal’ off the shelf cell therapy, as well as other areas.

5. Immunotherapy strategies: autologous adoptive cell therapy.

Natural killer (NK) cells are considered to be critical players in anticancer immunity. Natural killer (NK) cells are key innate immune cells that provide the first line of defense against viral infection and cancer. The broad cytotoxicity and rapid killing make NK cells ideal for the use in cancer immunotherapy. So, whereas T cells have taken center stage in cancer immunotherapy – as the focus of treatments that sharpen the immune system's attack on cancer – NK cells are still mostly in the wings but edging closer to the spotlight. NK cell-based immunotherapy in ovarian cancer 5.1. Journal of Clinical Medicine Review Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy Alicia A. Gingrich 1, Jaime F. Modiano 2 and Robert J. Canter 1,* 1 Department of Surgery, University of California Davis, 2221 Stockton Blvd, Sacramento, CA 95817, USA; As effectors of cancer immunotherapy, NK cells are attractive as they do not attack healthy self-tissues nor do they induce T cell-driven inflammatory cytokine storm, enabling their use as allogeneic adoptive cellular therapies.

To bestow tumor-targeting abilities and enhance anticancer efficacy, a new strategy is established to glycoengineer NK cells. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment. In cancer therapy, dendritic cell (DC) vaccination is still being explored.

[] reported an approximate 30-fold expansion of NK cells after 18 days of culture with 1000 IU/mL IL-2 and monocytes.

Immunotherapy for Cancer Treatment As cancer cells grow and spread, they adapt and learn new ways to avoid being eliminated by the immune system. However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cells. Natural Killer T-Cells B-Lymphocytes Antigens Keywords IL-15 IL-2 immunotherapy inhibitory receptor natural killer cell Cite this APA Standard Harvard Vancouver Author BIBTEX RIS Miller, J. S., & Lanier, L. L. (2019). Recent progress in our understanding of NK cell immunobiology has paved the way for novel NK cell-based therapeutic strategies for the treatment of cancer. 1 Interleukin-2 (IL-2)–activated haploidentical NK (haplo-NK) cell therapy induces complete remission (CR) in 30% to 50% of patients with relapsed and/or refractory acute myeloid leukemia … While chimeric antigen receptors (CARs) have been used extensively to redirect the specificity of autologous T cells against hematological malignancies with striking clinical results, studies of CAR-modified natural killer (NK) cells … Cancer immunotherapy has been firmly established as a new milestone for cancer therapy, with the development of multiple immune cells as therapeutic tools.

Only in the minority of patients, T-cell responses correlate with clinical outcome, indicating that other immune cells also gain anticancer activity.

They recognise “non-self” cells without the need for antibodies and major histocompatibility complex (MHC), executing a rapid immune reaction. This has impelled the development of NKT cell-targeted immunotherapies for treating cancer. Current NK cell-based cancer immunotherapy is aimed at overcoming NK cell paralysis through several potential approaches, including activating autologous NK cells, expanding allogeneic NK cells, …

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